Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

BACKGROUND: Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing glyoxalase-1 (GLO-1) promoted the regeneration of ischemic lower limbs in diabetic mice, but low survival rate, difficulty in di...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Zhang, Xing, Jiang, Yihong, Huang, Qun, Wu, Zhaoyu, Pu, Hongji, Xu, Zhijue, Li, Bo, Lu, Xinwu, Yang, Xinrui, Qin, Jinbao, Peng, Zhiyou
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281719/
https://ncbi.nlm.nih.gov/pubmed/34266474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02475-7
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