Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

BACKGROUND: Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing glyoxalase-1 (GLO-1) promoted the regeneration of ischemic lower limbs in diabetic mice, but low survival rate, difficulty in di...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Zhang, Xing, Jiang, Yihong, Huang, Qun, Wu, Zhaoyu, Pu, Hongji, Xu, Zhijue, Li, Bo, Lu, Xinwu, Yang, Xinrui, Qin, Jinbao, Peng, Zhiyou
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281719/
https://ncbi.nlm.nih.gov/pubmed/34266474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02475-7
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