Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion

After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire latent Mtb infection (LTBI) defined by a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA). To identify mechanisms of resistance to Mtb infection, we compared transcriptional profiles from h...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Simmons, Jason D., Van, Phu T., Stein, Catherine M., Chihota, Violet, Ntshiqa, Thobani, Maenetje, Pholo, Peterson, Glenna J., Reynolds, Anthony, Benchek, Penelope, Velen, Kavindhran, Fielding, Katherine L., Grant, Alison D., Graustein, Andrew D., Nguyen, Felicia K., Seshadri, Chetan, Gottardo, Raphael, Mayanja-Kizza, Harriet, Wallis, Robert S., Churchyard, Gavin, Boom, W. Henry, Hawn, Thomas R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279582/
https://ncbi.nlm.nih.gov/pubmed/34111032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140073
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