Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion

After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire latent Mtb infection (LTBI) defined by a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA). To identify mechanisms of resistance to Mtb infection, we compared transcriptional profiles from h...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Simmons, Jason D., Van, Phu T., Stein, Catherine M., Chihota, Violet, Ntshiqa, Thobani, Maenetje, Pholo, Peterson, Glenna J., Reynolds, Anthony, Benchek, Penelope, Velen, Kavindhran, Fielding, Katherine L., Grant, Alison D., Graustein, Andrew D., Nguyen, Felicia K., Seshadri, Chetan, Gottardo, Raphael, Mayanja-Kizza, Harriet, Wallis, Robert S., Churchyard, Gavin, Boom, W. Henry, Hawn, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279582/
https://ncbi.nlm.nih.gov/pubmed/34111032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140073
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