Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

Interleukin 7 (IL-7) is a cell growth factor with a central role in normal T cell development, survival and differentiation. The lack of IL-7–IL-7 receptor(R)-mediated signaling compromises lymphoid development, whereas increased signaling activity contributes to the development of chronic inflammat...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Vandooren, Jennifer, Pereira, Rafaela Vaz Sousa, Ugarte-Berzal, Estefania, Rybakin, Vasily, Noppen, Sam, Stas, Melissa R., Bernaerts, Eline, Ganseman, Eva, Metzemaekers, Mieke, Schols, Dominique, Proost, Paul, Opdenakker, Ghislain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8278288/
https://ncbi.nlm.nih.gov/pubmed/34276694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.701739
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