Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression

Methods for quantifying gene expression(1) and chromatin accessibility(2) in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically challenging. In this study, we adapted the CUT&Tag method(3) to scalable nanowell...

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Udgivet i:Nat Biotechnol
Main Authors: Wu, Steven J., Furlan, Scott N., Mihalas, Anca B., Kaya-Okur, Hatice S., Feroze, Abdullah H., Emerson, Samuel N., Zheng, Ye, Carson, Kalee, Cimino, Patrick J., Keene, C. Dirk, Sarthy, Jay F., Gottardo, Raphael, Ahmad, Kami, Henikoff, Steven, Patel, Anoop P.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277750/
https://ncbi.nlm.nih.gov/pubmed/33846646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-021-00865-z
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