KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

Cellular senescence restrains the expansion of neoplastic cells through several layers of regulation. We report that the histone H3-specific demethylase KDM4 is expressed as human stromal cells undergo senescence. In clinical oncology, upregulated KDM4 and diminished H3K9/H3K36 methylation correlate...

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Gepubliceerd in:Nat Aging
Hoofdauteurs: Zhang, Boyi, Long, Qilai, Wu, Shanshan, Xu, Qixia, Song, Shuling, Han, Liu, Qian, Min, Ren, Xiaohui, Liu, Hanxin, Jiang, Jing, Guo, Jianming, Zhang, Xiaoling, Chang, Xing, Fu, Qiang, Lam, Eric W-F, Campisi, Judith, Kirkland, James L., Sun, Yu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277122/
https://ncbi.nlm.nih.gov/pubmed/34263179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43587-021-00063-1
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