High-Level Production of Lysine in the Yeast Saccharomyces cerevisiae by Rational Design of Homocitrate Synthase

Homocitrate synthase (HCS) catalyzes the aldol condensation of 2-oxoglutarate (2-OG) and acetyl coenzyme A (AcCoA) to form homocitrate, which is the first enzyme of the lysine biosynthetic pathway in the yeast Saccharomyces cerevisiae. The HCS activity is tightly regulated via feedback inhibition by...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Isogai, Shota, Matsushita, Tomonori, Imanishi, Hiroyuki, Koonthongkaew, Jirasin, Toyokawa, Yoichi, Nishimura, Akira, Yi, Xiao, Kazlauskas, Romas, Takagi, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276798/
https://ncbi.nlm.nih.gov/pubmed/33990312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00600-21
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