Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication

All coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in nonstructural protein 3 (nsp3) that binds and hydrolyzes mono-ADP-ribose (MAR) covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent virulence factor, there is still a limited understanding...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Voth, Lynden S., O’Connor, Joseph J., Kerr, Catherine M., Doerger, Ethan, Schwarting, Nancy, Sperstad, Parker, Johnson, David K., Fehr, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274620/
https://ncbi.nlm.nih.gov/pubmed/34011547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00766-21
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