The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs. While several PARPs have known antiviral activities, these activities...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Grunewald, Matthew E., Chen, Yating, Kuny, Chad, Maejima, Takashi, Lease, Robert, Ferraris, Dana, Aikawa, Masanori, Sullivan, Christopher S., Perlman, Stanley, Fehr, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521996/
https://ncbi.nlm.nih.gov/pubmed/31095648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007756
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