EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG

ONC201/TIC10 activates TRAIL signaling through ATF4 and the integrated stress response (ISR). ONC201 demonstrated tumor regressions and disease stability in patients with histone H3K27M-mutated midline-glioma. H3K27M-mutation prevents H3K27-methylation on the mutated allele. EZH2 inhibitors (EZH2i)...

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Bibliographische Detailangaben
Veröffentlicht in:Neoplasia
Hauptverfasser: Zhang, Yiqun, Zhou, Lanlan, Safran, Howard, Borsuk, Robyn, Lulla, Rishi, Tapinos, Nikos, Seyhan, Attila A., El-Deiry, Wafik S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2021
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274300/
https://ncbi.nlm.nih.gov/pubmed/34246076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.06.007
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