Ultrasound Microbubble–Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane

The application of ultrasound microbubbles (USMBs) enhances the permeability of the round window membrane (RWM) and improves drug delivery to the inner ear. In this study, we investigated the efficiency of USMB-aided delivery of chitosan-coated gold nanoparticles (CS-AuNPs) and the mechanism of USMB...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Lin, Yi-Chun, Shih, Cheng-Ping, Chen, Hsin-Chien, Chou, Ying-Liang, Sytwu, Huey-Kang, Fang, Mei-Cho, Lin, Yuan-Yung, Kuo, Chao-Yin, Su, Hsiao-Han, Hung, Chia-Lien, Chen, Hang-Kang, Wang, Chih-Hung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273281/
https://ncbi.nlm.nih.gov/pubmed/34262458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.689032
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