Ultrasound Microbubble–Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane

The application of ultrasound microbubbles (USMBs) enhances the permeability of the round window membrane (RWM) and improves drug delivery to the inner ear. In this study, we investigated the efficiency of USMB-aided delivery of chitosan-coated gold nanoparticles (CS-AuNPs) and the mechanism of USMB...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lin, Yi-Chun, Shih, Cheng-Ping, Chen, Hsin-Chien, Chou, Ying-Liang, Sytwu, Huey-Kang, Fang, Mei-Cho, Lin, Yuan-Yung, Kuo, Chao-Yin, Su, Hsiao-Han, Hung, Chia-Lien, Chen, Hang-Kang, Wang, Chih-Hung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273281/
https://ncbi.nlm.nih.gov/pubmed/34262458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.689032
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