Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine

BACKGROUND: The round window membrane (RWM) functions as the primary biological barrier for therapeutic agents in the inner ear via local application. Previous studies on inner ear nano-drug delivery systems mostly focused on their pharmacokinetics and distribution in the inner ear, but seldom on th...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Zhang, Liping, Xu, Yuan, Cao, Wenjuan, Xie, Shibao, Wen, Lu, Chen, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784583/
https://ncbi.nlm.nih.gov/pubmed/29403277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S154968
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