YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m(6)A modification to activate NF-κB and promote the malignant progression of glioma

BACKGROUND: The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m(6)A) reader, YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), in regul...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Hematol Oncol
Main Authors: Chai, Rui-Chao, Chang, Yu-Zhou, Chang, Xin, Pang, Bo, An, Song Yuan, Zhang, Ke-Nan, Chang, Yuan-Hao, Jiang, Tao, Wang, Yong-Zhi
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272379/
https://ncbi.nlm.nih.gov/pubmed/34246306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-021-01124-z
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