Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity

Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophoric point of tubulin binding and anti-cancer activity. As the c...

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Publicado en:Molecules
Main Authors: Liu, Xu, Pang, Xiao-Jing, Liu, Yuan, Liu, Wen-Bo, Li, Yin-Ru, Yu, Guang-Xi, Zhang, Yan-Bing, Song, Jian, Zhang, Sai-Yang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272053/
https://ncbi.nlm.nih.gov/pubmed/34279387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26134047
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