Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes

Antimicrobial peptides (AMPs) contribute to an effective protection against infections. The antibacterial function of AMPs depends on their interactions with microbial membranes and lipids, such as lipopolysaccharide (LPS; endotoxin). Hyperinflammation induced by endotoxin is a key factor in bacteri...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Schromm, Andra B., Paulowski, Laura, Kaconis, Yani, Kopp, Franziska, Koistinen, Max, Donoghue, Annemarie, Keese, Susanne, Nehls, Christian, Wernecke, Julia, Garidel, Patrick, Sevcsik, Eva, Lohner, Karl, Sanchez-Gomez, Susana, Martinez-de-Tejada, Guillermo, Brandenburg, Klaus, Brameshuber, Mario, Schütz, Gerhard J., Andrä, Jörg, Gutsmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271772/
https://ncbi.nlm.nih.gov/pubmed/34183393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101721118
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