High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

BACKGROUND: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the causal role of correlated risk factors with shared genetic predictors....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Epidemiol
Egile Nagusiak: Zuber, Verena, Gill, Dipender, Ala-Korpela, Mika, Langenberg, Claudia, Butterworth, Adam, Bottolo, Leonardo, Burgess, Stephen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Cardiovascular Risks
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271202/
https://ncbi.nlm.nih.gov/pubmed/33130851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyaa216
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