Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Microbial biofilms are involved in a number of infections that cannot be cured, as microbes in biofilms resist host immune defenses and antibiotic therapies. With no strict biofilm-antibiotic in the current pipelines, there is an unmet need for drug candidates that enable the current antibiotics to...

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Publicado no:NPJ Biofilms Microbiomes
Main Authors: Andersen, Jens Bo, Hultqvist, Louise Dahl, Jansen, Charlotte Uldahl, Jakobsen, Tim Holm, Nilsson, Martin, Rybtke, Morten, Uhd, Jesper, Fritz, Blaine Gabriel, Seifert, Roland, Berthelsen, Jens, Nielsen, Thomas Eiland, Qvortrup, Katrine, Givskov, Michael, Tolker-Nielsen, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271024/
https://ncbi.nlm.nih.gov/pubmed/34244523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41522-021-00225-4
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