Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Attenuation of Pseudomonas aeruginosa virulence by the use of small-molecule quorum-sensing inhibitors (referred to as the antipathogenic drug principle) is likely to play a role in future treatment strategies for chronic infections. In this study, structure-based virtual screening was used in a sea...

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Bibliografiske detaljer
Main Authors: Yang, Liang, Rybtke, Morten Theil, Jakobsen, Tim Holm, Hentzer, Morten, Bjarnsholt, Thomas, Givskov, Michael, Tolker-Nielsen, Tim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687250/
https://ncbi.nlm.nih.gov/pubmed/19364871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01283-08
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