The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense and respond to remain unclear. Here we show that the rate of force application (loading rate) drives mechanosensing, as predicted by a molecular clutch model. By...

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Udgivet i:Nat Commun
Main Authors: Andreu, Ion, Falcones, Bryan, Hurst, Sebastian, Chahare, Nimesh, Quiroga, Xarxa, Le Roux, Anabel-Lise, Kechagia, Zanetta, Beedle, Amy E. M., Elosegui-Artola, Alberto, Trepat, Xavier, Farré, Ramon, Betz, Timo, Almendros, Isaac, Roca-Cusachs, Pere
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270983/
https://ncbi.nlm.nih.gov/pubmed/34244477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24383-3
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