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The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense and respond to remain unclear. Here we show that the rate of force application (loading rate) drives mechanosensing, as predicted by a molecular clutch model. By...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8270983/ https://ncbi.nlm.nih.gov/pubmed/34244477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24383-3 |
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