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De novo mutational signature discovery in tumor genomes using SparseSignatures
Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or “mutational signatures”. Here we present SparseSignatures, a novel framework to extract signatures from somatic point mutation data. Our approach incorporates a user-s...
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| Udgivet i: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8270462/ https://ncbi.nlm.nih.gov/pubmed/34181655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1009119 |
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