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Amino Acid-Mediated Intracellular Ca(2+) Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca(2+)/Calmodulin
Mechanistic target of rapamycin complex 1 (mTORC1) is a master growth regulator by controlling protein synthesis and autophagy in response to environmental cues. Amino acids, especially leucine and arginine, are known to be important activators of mTORC1 and to promote lysosomal translocation of mTO...
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| Publicado no: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8269083/ https://ncbi.nlm.nih.gov/pubmed/34198993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136897 |
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