A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress

SIMPLE SUMMARY: γ-H2AX, a phosphorylated variant of histone H2A, is a widely used biomarker of DNA replication stress. To develop an immunological probe able to detect and track γ-H2AX in live cancer cells, we have isolated single domain antibodies (called nanobodies) that are easily expressed as fu...

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Pubblicato in:Cancers (Basel)
Autori principali: Moeglin, Eric, Desplancq, Dominique, Stoessel, Audrey, Massute, Christian, Ranniger, Jeremy, McEwen, Alastair G., Zeder-Lutz, Gabrielle, Oulad-Abdelghani, Mustapha, Chiper, Manuela, Lafaye, Pierre, Di Ventura, Barbara, Didier, Pascal, Poterszman, Arnaud, Weiss, Etienne
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267817/
https://ncbi.nlm.nih.gov/pubmed/34282773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13133317
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