Generation of an alpaca-derived nanobody recognizing γ-H2AX

Post-translational modifications are difficult to visualize in living cells and are conveniently analyzed using antibodies. Single-chain antibody fragments derived from alpacas and called nanobodies can be expressed and bind to the target antigenic sites in living cells. As a proof of concept, we ge...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Rajan, Malini, Mortusewicz, Oliver, Rothbauer, Ulrich, Hastert, Florian D., Schmidthals, Katrin, Rapp, Alexander, Leonhardt, Heinrich, Cardoso, M. Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588710/
https://ncbi.nlm.nih.gov/pubmed/26500838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.09.005
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