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mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells
We examined the effects of mTOR inhibitors on the fibrotic response induced by transforming growth factor-beta2 (TGF-β2) in cultured human trabecular meshwork (hTM) cells. TGF-β2-induced expression of fibronectin, collagen type I, alpha 1 chain (COL1A1), and alpha-smooth muscle actin (αSMA) in hTM c...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266857/ https://ncbi.nlm.nih.gov/pubmed/34239027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93580-3 |
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