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Regulation of Rac1 transcription by histone and DNA methylation in diabetic retinopathy
Cytosolic ROS, generated by NADPH oxidase 2 (Nox2) in diabetes, damage retinal mitochondria, which leads to the development of retinopathy. A small molecular weight G-protein essential for Nox2 activation, Rac1, is also transcriptionally activated via active DNA methylation-hydroxymethylation. DNA m...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266843/ https://ncbi.nlm.nih.gov/pubmed/34238980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93420-4 |
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