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Functional Regulation of an Oxidative Stress Mediator, Rac1, in Diabetic Retinopathy
PURPOSE: Early activation of cytosolic NADPH oxidase-2 (Nox2) in diabetes increases retinal ROS production, damaging their mitochondria. The assembly of Nox2 holoenzyme requires activation of a small molecular weight G-protein Rac1. Rac1 activation is regulated by guanine exchange factors) and guani...
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| I publikationen: | Mol Neurobiol |
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| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6842106/ https://ncbi.nlm.nih.gov/pubmed/31300985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01696-5 |
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