A Polygenic Risk Score to Predict Future Adult Short Stature Among Children

CONTEXT: Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height. OBJECTIVE: To develop a polygenic risk score for adult height and evaluate its clinical utility. DESIGN: A polygenic risk score was constructed based on meta-analysi...

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Dettagli Bibliografici
Pubblicato in:J Clin Endocrinol Metab
Autori principali: Lu, Tianyuan, Forgetta, Vincenzo, Wu, Haoyu, Perry, John R B, Ong, Ken K, Greenwood, Celia M T, Timpson, Nicholas J, Manousaki, Despoina, Richards, J Brent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Clinical Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266463/
https://ncbi.nlm.nih.gov/pubmed/33788949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgab215
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