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Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 p...
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| Udgivet i: | J Enzyme Inhib Med Chem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266253/ https://ncbi.nlm.nih.gov/pubmed/34227437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1937142 |
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