Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred at positions C-2 and/or C-4. The potential inhibitory action of the halogenated estrones on human aromatase, steroid sulfatase, or 17β-hydroxy...

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Publicado en:J Enzyme Inhib Med Chem
Autores principales: Bacsa, Ildikó, Herman, Bianka Edina, Jójárt, Rebeka, Herman, Kevin Stefán, Wölfling, János, Schneider, Gyula, Varga, Mónika, Tömböly, Csaba, Rižner, Tea Lanišnik, Szécsi, Mihály, Mernyák, Erzsébet
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147116/
https://ncbi.nlm.nih.gov/pubmed/30230387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1490731
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