NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells

Microglia are the resident immune cell of the brain involved in the development and progression of Alzheimer’s disease (AD). Modulation of microglia activity represents a potential mechanism for treating AD. Herein, the compound NNC 26–9100 (NNC) was evaluated in toxicity, nitric oxide release, Aβ(1...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Schober, Joseph, Polina, Jahnavi, Walters, Field, Scott, Nathan, Lodholz, Eric, Crider, Albert, Sandoval, Karin, Witt, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266108/
https://ncbi.nlm.nih.gov/pubmed/34237100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254242
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