Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism

Soluble amyloid-β peptide (Aβ) oligomers have been hypothesized to be primary mediators of Alzheimer’s disease progression. In this regard, reduction of soluble Aβ-oligomers levels within the brain may provide a viable means in which to treat the disease. Somatostatin receptor subtype-4 (SSTR4) agon...

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Main Authors: Sandoval, Karin E., Farr, Susan A., Banks, William A., Crider, Albert M., Morley, John E., Witt, Ken A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686878/
https://ncbi.nlm.nih.gov/pubmed/23669069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.05.006
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