Growth Hormone Receptor Gene Disruption in Mature-Adult Mice Improves Glucose Metabolism and Lifespan in Females

Growth hormone (GH) serves an important role in early and adult life. Reduction of GH action has been shown to increase life span in many species of animals. In fact, mice bearing a congenital disruption of GH receptor (GHR) gene (GHRKO) hold the record for the longest-lived laboratory mice. In addi...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Duran-Ortiz, Silvana, List, Edward O, Bell, Stephen, Basu, Reetobrata, Young, Jonathan, McHugh, Todd, Mathes, Samuel Casey, Funk, Kevin Ray, Qian, Yanrong, Berryman, Darlene E, Kopchick, John Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Diabetes Mellitus and Glucose Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265872/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.910
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