Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma

Growth hormone (GH) facilitates therapy resistance in the cancers of breast, colon, endometrium, and melanoma. The GH-stimulated pathways responsible for this resistance were identified as suppression of apoptosis, induction of epithelial-to-mesenchymal transition (EMT), and upregulated drug efflux...

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Publicado en:Cancers (Basel)
Autores principales: Basu, Reetobrata, Kulkarni, Prateek, Qian, Yanrong, Walsh, Christopher, Arora, Pranay, Davis, Emily, Duran-Ortiz, Silvana, Funk, Kevin, Ibarra, Diego, Kruse, Colin, Mathes, Samuel, McHugh, Todd, Brittain, Alison, Berryman, Darlene E., List, Edward O., Okada, Shigeru, Kopchick, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769493/
https://ncbi.nlm.nih.gov/pubmed/31547367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091352
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