SAT-181 Characterization of Adult Growth Hormone Receptor Gene-Disrupted Mice

Reduced growth hormone (GH) action can extend life- and health-span. Mice with a disrupted GHR gene since birth are dwarf and obese with low levels of IGF-1 and insulin; high levels of GH; and hold the record for the longest-lived laboratory mouse. They are also somewhat resistant to several age-rel...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Duran-Ortiz, Silvana, List, Edward, Berryman, Darlene, Bell, Stephen, Funk, Kevin, Basu, Reetobrata, Qian, Yanrong, Young, Jonathan, Kopchick, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2019
Schlagworte:
Diabetes Mellitus and Glucose Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552003/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-181
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