Effects of the Local Bone Renin-Angiotensin System on Titanium-Particle-Induced Periprosthetic Osteolysis

Wear particles may induce osteoclast formation and osteoblast inhibition that lead to periprosthetic osteolysis (PPOL) and subsequent aseptic loosening, which is the primary reason for total joint arthroplasty failure. Local bone renin-angiotensin system (RAS) has been found to participate in the pa...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Zhao, Zhiping, Wang, Changyao, Xu, Yingxing, Wang, Xiangyu, Jia, Bin, Yu, Tengbo, Wang, Yingzhen, Zhang, Yongtao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264785/
https://ncbi.nlm.nih.gov/pubmed/34248634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.684375
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