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Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) still depicts an incurable and devastating disease. Drug development efforts are mostly based on superoxide dismutase 1 gene (SOD1)-G93A mice that present a very strong and early phenotype, allowing only a short time window for intervention. An alternative mouse m...

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Pubblicato in:Front Mol Neurosci
Autori principali: Molnar-Kasza, Agnes, Hinteregger, Barbara, Neddens, Joerg, Rabl, Roland, Flunkert, Stefanie, Hutter-Paier, Birgit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264456/
https://ncbi.nlm.nih.gov/pubmed/34248499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.681868
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