Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation

The integration of circadian and metabolic signals is essential for maintaining robust circadian rhythms and ensuring efficient metabolism and energy use. Using Drosophila as an animal model, we show that cellular protein O-GlcNAcylation exhibits robust 24-hour rhythm and represents a key post-trans...

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Udgivet i:Nat Commun
Main Authors: Liu, Xianhui, Blaženović, Ivana, Contreras, Adam J., Pham, Thu M., Tabuloc, Christine A., Li, Ying H., Ji, Jian, Fiehn, Oliver, Chiu, Joanna C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263742/
https://ncbi.nlm.nih.gov/pubmed/34234137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24301-7
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