Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermi...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:mBio
Main Authors: Gonçalves, Samuel M., Antunes, Daniela, Leite, Luis, Mercier, Toine, ter Horst, Rob, Vieira, Joana, Espada, Eduardo, Pinho Vaz, Carlos, Branca, Rosa, Campilho, Fernando, Freitas, Fátima, Ligeiro, Dário, Marques, António, van de Veerdonk, Frank L., Joosten, Leo A. B., Lagrou, Katrien, Maertens, Johan, Netea, Mihai G., Lacerda, João F., Campos, António, Cunha, Cristina, Carvalho, Agostinho
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263003/
https://ncbi.nlm.nih.gov/pubmed/34044589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00369-21
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