Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermi...

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Pubblicato in:mBio
Autori principali: Gonçalves, Samuel M., Antunes, Daniela, Leite, Luis, Mercier, Toine, ter Horst, Rob, Vieira, Joana, Espada, Eduardo, Pinho Vaz, Carlos, Branca, Rosa, Campilho, Fernando, Freitas, Fátima, Ligeiro, Dário, Marques, António, van de Veerdonk, Frank L., Joosten, Leo A. B., Lagrou, Katrien, Maertens, Johan, Netea, Mihai G., Lacerda, João F., Campos, António, Cunha, Cristina, Carvalho, Agostinho
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263003/
https://ncbi.nlm.nih.gov/pubmed/34044589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00369-21
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