Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermi...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Gonçalves, Samuel M., Antunes, Daniela, Leite, Luis, Mercier, Toine, ter Horst, Rob, Vieira, Joana, Espada, Eduardo, Pinho Vaz, Carlos, Branca, Rosa, Campilho, Fernando, Freitas, Fátima, Ligeiro, Dário, Marques, António, van de Veerdonk, Frank L., Joosten, Leo A. B., Lagrou, Katrien, Maertens, Johan, Netea, Mihai G., Lacerda, João F., Campos, António, Cunha, Cristina, Carvalho, Agostinho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263003/
https://ncbi.nlm.nih.gov/pubmed/34044589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00369-21
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