Wnt–β-catenin activation epigenetically reprograms T(reg) cells in inflammatory bowel disease and dysplastic progression

The diversity of regulatory T (T(reg)) cells in health and in disease remains unclear. Individuals with colorectal cancer harbor a subpopulation of RORγt(+) T(reg) cells with elevated expression of β-catenin and pro-inflammatory properties. Here we show progressive expansion of RORγt(+) T(reg) cells...

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Détails bibliographiques
Publié dans:Nat Immunol
Auteurs principaux: Quandt, Jasmin, Arnovitz, Stephen, Haghi, Leila, Woehlk, Janine, Mohsin, Azam, Okoreeh, Michael, Mathur, Priya S., Emmanuel, Akinola Olumide, Osman, Abu, Krishnan, Manisha, Morin, Samuel B., Pearson, Alexander T., Sweis, Randy F., Pekow, Joel, Weber, Christopher R., Khazaie, Khashayarsha, Gounari, Fotini
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262575/
https://ncbi.nlm.nih.gov/pubmed/33664518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00889-2
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