Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance, but the exact identity of lipid-mediated mechanisms relevant to human obesity remains unclear. A comprehensive lipidomic analysis of primary myocytes from individuals who were insulin-sensitive and lean (LN) or...

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Pubblicato in:J Clin Invest
Autori principali: Ferrara, Patrick J., Rong, Xin, Maschek, J. Alan, Verkerke, Anthony R.P., Siripoksup, Piyarat, Song, Haowei, Green, Thomas D., Krishnan, Karthickeyan C., Johnson, Jordan M., Turk, John, Houmard, Joseph A., Lusis, Aldons J., Drummond, Micah J., McClung, Joseph M., Cox, James E., Shaikh, Saame Raza, Tontonoz, Peter, Holland, William L., Funai, Katsuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262507/
https://ncbi.nlm.nih.gov/pubmed/33591957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135963
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