11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration

BACKGROUND: Continued androgen receptor (AR) signaling constitutes a key target for treatment in metastatic castration-resistant prostate cancer (CRPC). Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically relevant concent...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Snaterse, Gido, van Dessel, Lisanne F., van Riet, Job, Taylor, Angela E., van der Vlugt-Daane, Michelle, Hamberg, Paul, de Wit, Ronald, Visser, Jenny A., Arlt, Wiebke, Lolkema, Martijn P., Hofland, Johannes
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262344/
https://ncbi.nlm.nih.gov/pubmed/33974560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.148507
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