CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity

Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the m...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Filppu, Pauliina, Tanjore Ramanathan, Jayendrakishore, Granberg, Kirsi J., Gucciardo, Erika, Haapasalo, Hannu, Lehti, Kaisa, Nykter, Matti, Le Joncour, Vadim, Laakkonen, Pirjo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262342/
https://ncbi.nlm.nih.gov/pubmed/33986188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141486
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