Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis

Lupus nephritis (LN) is a serious complication occurring in 50% of patients with systemic lupus erythematosus (SLE) for which there is a lack of biomarkers, a lack of specific medications, and a lack of a clear understanding of its pathogenesis. The expression of calcium/calmodulin kinase IV (CaMK4)...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Bhargava, Rhea, Lehoux, Sylvain, Maeda, Kayaho, Tsokos, Maria G., Krishfield, Suzanne, Ellezian, Lena, Pollak, Martin, Stillman, Isaac E., Cummings, Richard D., Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262331/
https://ncbi.nlm.nih.gov/pubmed/33784256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147789
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