IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here, we report a possibly novel approach to rapid gen...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: de Mattos Barbosa, Mayara Garcia, Liu, Hui, Huynh, Daniel, Shelley, Greg, Keller, Evan T., Emmer, Brian T., Sherman, Emily, Ginsburg, David, Kennedy, Andrew A., Tai, Andrew W., Wobus, Christiane, Mirabeli, Carmen, Lanigan, Thomas M., Samaniego, Milagros, Meng, Wenzhao, Rosenfeld, Aaron M., Prak, Eline T. Luning, Platt, Jeffrey L., Cascalho, Marilia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262290/
https://ncbi.nlm.nih.gov/pubmed/33769311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147386
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