IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here, we report a possibly novel approach to rapid gen...

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發表在:JCI Insight
Main Authors: de Mattos Barbosa, Mayara Garcia, Liu, Hui, Huynh, Daniel, Shelley, Greg, Keller, Evan T., Emmer, Brian T., Sherman, Emily, Ginsburg, David, Kennedy, Andrew A., Tai, Andrew W., Wobus, Christiane, Mirabeli, Carmen, Lanigan, Thomas M., Samaniego, Milagros, Meng, Wenzhao, Rosenfeld, Aaron M., Prak, Eline T. Luning, Platt, Jeffrey L., Cascalho, Marilia
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262290/
https://ncbi.nlm.nih.gov/pubmed/33769311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147386
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