IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here, we report a possibly novel approach to rapid gen...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: de Mattos Barbosa, Mayara Garcia, Liu, Hui, Huynh, Daniel, Shelley, Greg, Keller, Evan T., Emmer, Brian T., Sherman, Emily, Ginsburg, David, Kennedy, Andrew A., Tai, Andrew W., Wobus, Christiane, Mirabeli, Carmen, Lanigan, Thomas M., Samaniego, Milagros, Meng, Wenzhao, Rosenfeld, Aaron M., Prak, Eline T. Luning, Platt, Jeffrey L., Cascalho, Marilia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262290/
https://ncbi.nlm.nih.gov/pubmed/33769311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147386
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