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Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation
Proteolysis targeting chimeras (PROTAC) represents a new type of small molecule induced protein degradation technology that has emerged in recent years. PROTAC uses bifunctional small molecules to induce ubiquitination of target proteins and utilizes intracellular proteasomes for chemical knockdown....
Shranjeno v:
| izdano v: | Front Cell Dev Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8261656/ https://ncbi.nlm.nih.gov/pubmed/34249939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.685106 |
| Oznake: |
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